Bus from St. Louis to Chicago and from Chicago to St. Louis

Let the Windy City blow you away. Our bus from St. Louis to Chicago brings you within reach of one of the hottest tourist destinations in the Midwest. Chi-town is an unforgettable blend of art, culture, and history. We dare you to attempt to eat a Chicago-style deep dish pizza without getting sauce on your shirt. Absorb Chicago’s rich architectural successes by visiting Millennium Park or simply check out the Chicago skyline. Our St. Louis to Chicago route solves your Midwest travel plans.

Get a better view of the Gateway Arch on your next trip to St. Louis.

St. Louis is an aesthetically beautiful city that's filled with attractions for any kind of traveler.

Get fired up at a Rams, Cardinals, or Blues game, check out Six Flags St. Louis, or spend a night on the town with its electrifying nightlife and music scene.

Feast upon the amazing local grub, visit the many wonderful museums, or explore the city's local parks.

Perfect your Midwest travel and book a bus from Chicago to St. Louis today!

What amenities are included on a bus from St. Louis to Chicago?

individual power outlets
reclining seats
reserved seating
fares starting at just $1*

When you ride with us, you could catch up on all of your TV shows. Just don't reveal any spoilers to your bus neighbors!

Whether your bus trip from St. Louis to Chicago or Chicago to St. Louis is for business or leisure, Megabus will get you there comfortably and conveniently.

All of our seats on buses from St. Louis to Chicago are equipped with onboard restrooms, individual power outlets, three-point seatbelts, and reclining seats.

Plus, when booking your bus tickets from St. Louis to Chicago, you’re given multiple seating upgrade options to ensure your experience is as comfortable and relaxing as possible.

On all of our buses from St. Louis to Chicago and Chicago to St. Louis, we offer reserved seating.

Reserve one of the 10 most popular seats on our buses to enjoy a more spacious ride or secure seats next to family and friends (assuming you like them).

Remember that reserved seats are limited, so make sure to plan ahead and book early for your St. Louis to Chicago trip!

Route information for the bus from St. Louis to Chicago

Our bus from St. Louis to Chicago happens to be one of our most popular routes among our network of over 100 cities across North America, allowing you flexible scheduling.

With convenient departure times, Megabus makes planning your next St. Louis to Chicago to trip simple.

Keep track of your St. Louis to Chicago itinerary online, easily accessible from your smartphone.

Bus stop locations and drop-off locations in St. Louis and Chicago

Whether you’re traveling by bus from St. Louis to Chicago or vice versa, you will be centrally located for hotels, restaurants, and public transit when you arrive.

When traveling by bus from Chicago to St. Louis, you will depart from Van Buren Street between South Canal and Clinton Street.

Your Chicago to St. Louis bus will arrive at the Gateway Transportation Center at 430 South 15th Street.

Learn more about St. Louis and things to do by visiting our city guide.

When you travel by bus from St. Louis to Chicago, you will depart from Bay 10 of the Gateway Multi-Modal Transportation Center at 430 South 15th Street.

Your St. Louis to Chicago bus will arrive at Van Buren Street between South Canal and Clinton Street.

Learn more about Chicago and its sights by visiting our city guide.

You can check your reservation for the exact location and time of departure anytime online or from your smartphone.

Bus ticket prices for the bus from St. Louis to Chicago

When booking in advance, you can save big on bus ticket pricing from St. Louis to Chicago.

Megabus makes bus travel easy and affordable for your upcoming St. Louis to Chicago trip, with fares as low as $1*.

Reserving your bus tickets for your next St. Louis to Chicago trip is made simple online or by smartphone.

Our trip planner allows you to choose your flexible schedule for your St. Louis to Chicago or Chicago to St. Louis trip and find the itinerary that works for you.

Availability and booking for a bus from St. Louis to Chicago

So if you’re planning on traveling by bus from St. Louis to Chicago or from Chicago to St. Louis, book your ticket with us today to reserve your seat and see our first-class amenities firsthand.

Learn more about fun things to do in St. Louis or Chicago when you arrive.