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Bus from Syracuse to Buffalo

Book your bus ticket to Buffalo from Syracuse today

Duration 3 hours 09 minutes (fastest time)

Departures Up to 2 services per day

Why travel with megabus?

Power outlets onboard*

Express service

Green certified

* Subject to availability

Syracuse to Buffalo bus details

Our route AT01 bus stops at 4 stops between Syracuse and Buffalo. The bus sets off from Syracuse Regional Transit Center and drops you off at Trailways Bus Stop - Downtown Terminal at 181 Ellicott St


Arrivals and departures are located at the curbside in front of the William F Walsh Regional Transportation Center on the north side of the city. Connections are available to the CENTRO regional bus system.

Buffalo and Fullington Trailways arrivals and departures are located in the Metropolitan Transportation Center terminal building at 181 Ellicott Street.

Plan your bus trip to Buffalo

Bus from Syracuse to Buffalo with megabus

Our Buses

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* Subject to availability

Frequently Asked Questions

How long does it take to travel from Syracuse to Buffalo by bus?

The fastest bus from Syracuse to Buffalo takes 3 hours 09 minutes

When is the first bus from Syracuse to Buffalo?

The earliest bus from Syracuse to Buffalo leaves at 12:01 AM

When is the last bus from Syracuse to Buffalo?

The latest bus from Syracuse to Buffalo leaves at 3:05 PM

How many daily bus trips are there from Syracuse to Buffalo?

Megabus runs up to 2 trips per day from Syracuse to Buffalo