Bus from Syracuse to Buffalo
Book your bus ticket to Buffalo from Syracuse today
Duration 3 hours 09 minutes (fastest time)
Departures Up to 2 services per day
Why travel with megabus?
Power outlets onboard*
Express service
Green certified
* Subject to availability
Syracuse to Buffalo bus details
Our route AT01 bus stops at 4 stops between Syracuse and Buffalo. The bus sets off from Syracuse Regional Transit Center and drops you off at Trailways Bus Stop - Downtown Terminal at 181 Ellicott St
Syracuse
Arrivals and departures are located at the curbside in front of the William F Walsh Regional Transportation Center on the north side of the city. Connections are available to the CENTRO regional bus system.
Buffalo
Megabus.com and Fullington Trailways arrivals and departures are located in the Metropolitan Transportation Center terminal building at 181 Ellicott Street.
Our Buses
We are very proud of our fleet of state of the art buses.
- Individual power outlets*
- Reclining seats
- Reserved seating
- Onboard Restrooms
- Travel in luxury with megabus
* Subject to availability
Frequently Asked Questions
How long does it take to travel from Syracuse to Buffalo by bus?
The fastest bus from Syracuse to Buffalo takes 3 hours 09 minutes
When is the first bus from Syracuse to Buffalo?
The earliest bus from Syracuse to Buffalo leaves at 12:01 AM
When is the last bus from Syracuse to Buffalo?
The latest bus from Syracuse to Buffalo leaves at 3:05 PM
How many daily bus trips are there from Syracuse to Buffalo?
Megabus runs up to 2 trips per day from Syracuse to Buffalo