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Bus from Buffalo to Syracuse

Book your bus ticket to Syracuse from Buffalo today

Duration 3 hours 15 minutes (fastest time)

Departures Up to 3 services per day

Why travel with megabus?

Power outlets onboard*

Express service

Green certified

* Subject to availability

Buffalo to Syracuse bus details

Our route AT01 bus stops at 4 stops between Buffalo and Syracuse. The bus sets off from Trailways Bus Stop - Downtown Terminal at 181 Ellicott St and drops you off at Syracuse Regional Transit Center

Buffalo and Fullington Trailways arrivals and departures are located in the Metropolitan Transportation Center terminal building at 181 Ellicott Street.

Plan your bus trip to Buffalo


Arrivals and departures are located at the curbside in front of the William F Walsh Regional Transportation Center on the north side of the city. Connections are available to the CENTRO regional bus system.
Bus from Buffalo to Syracuse with megabus

Our Buses

We are very proud of our fleet of state of the art buses.

* Subject to availability

Frequently Asked Questions

How long does it take to travel from Buffalo to Syracuse by bus?

The fastest bus from Buffalo to Syracuse takes 3 hours 15 minutes

When is the first bus from Buffalo to Syracuse?

The earliest bus from Buffalo to Syracuse leaves at 12:15 AM

When is the last bus from Buffalo to Syracuse?

The latest bus from Buffalo to Syracuse leaves at 11:30 AM

How many daily bus trips are there from Buffalo to Syracuse?

Megabus runs up to 3 trips per day from Buffalo to Syracuse