Bus from Des Moines to Chicago and from Chicago to Des Moines

Let the Windy City blow you away. Our bus from Des Moines to Chicago brings you within reach of one of the hottest tourist destinations in the Midwest. Chi-town is an unforgettable blend of art, culture, and history. We dare you to attempt to eat a Chicago-style deep dish pizza without getting sauce on your shirt. Absorb Chicago’s rich architectural successes by visiting Millennium Park or simply check out the Chicago skyline. Our Des Moines to Chicago route solves your Midwest travel plans.

Home of the annual Iowa State Fair and much more, Des Moines is an enriching travel destination fit for your next trip.

Downtown Des Moines provides countless locally-owned restaurants, farmer's markets, public art, and an exciting nightlife.

While in town check out the Science Center of Iowa, the Blank Park Zoo, or catch a Broadway show at the Des Moines Civic Center.

Tell your friends that you're visiting the largest city in Iowa and book your next bus trip from Chicago to Des Moines to today!

Route information for the bus from Des Moines to Chicago

Our bus from Des Moines to Chicago happens to be one of our most popular routes among our network of over 500 cities across North America, allowing you flexible scheduling.

With convenient departure times, Megabus makes planning your next Des Moines to Chicago to trip simple.

Keep track of your Des Moines to Chicago itinerary online, easily accessible from your smartphone.

Bus stop locations and drop-off locations in Des Moines and Chicago

Whether you’re traveling by bus from Des Moines to Chicago or vice versa, you will be centrally located for hotels, restaurants, and public transit when you arrive.

Before you travel from Chicago to Des Moines, you'll want to know where you have to go to get on the bus. Visit our bus stops page for the precise location of your stop.

Learn more about Des Moines and things to do by visiting our city guide.

Learn more about Chicago and its sights by visiting our city guide.

You can check your reservation for the exact location and time of departure anytime online or from your smartphone.

Bus ticket prices for the bus from Des Moines to Chicago

When booking in advance, you can save big on bus ticket pricing from Des Moines to Chicago.

Megabus makes bus travel easy and affordable for your upcoming Des Moines to Chicago trip.

Reserving your bus tickets for your next Des Moines to Chicago trip is made simple online or by smartphone.

Our trip planner allows you to choose your flexible schedule for your Des Moines to Chicago or Chicago to Des Moines trip and find the itinerary that works for you.

Availability and booking for a bus from Des Moines to Chicago

So if you’re planning on traveling by bus from Des Moines to Chicago or from Chicago to Des Moines, book your ticket with us today to reserve your seat and see our first-class amenities firsthand.

Learn more about fun things to do in Des Moines or Chicago when you arrive.