Bus from Chicago to Louisville and from Louisville to Chicago

Open yourself up to the Gateway to the South. Brimming with Southern and Midwestern culture, Louisville offers a culturally rich and vibrant city with many attractions. Come for the famous horse races such as the Kentucky Derby, the parks, like beautiful Waterfront Park, or the multiple shopping districts downtown. Our bus from Chicago to Louisville drops you off nearby downtown, so you'll be nearby museums, restaurants, and amazing sights. Practice your Louisville pronunciation and book your Chicago to Louisville trip today!

Let the Windy City blow you away. Our bus from Louisville to Chicago brings you within reach of one of the hottest tourist destinations in the Midwest.

Chicago is an unforgettable blend of art, culture, and history. We dare you to attempt to eat a Chicago-style deep dish pizza without getting sauce on your shirt.

Absorb Chicago’s rich architectural successes by visiting Millennium Park or simply check out the Chicago skyline.

Our Chicago to Louisville route solves your Midwest travel plans.

What amenities are included on a bus from Chicago to Louisville?

individual power outlets
reclining seats
reserved seating
fares starting at just $1*

Be careful, riding with Megabus is addicting! You may find yourself booking again and again and again.

Whether your bus trip from Chicago to Louisville or Louisville to Chicago is for business or leisure, Megabus will get you there comfortably and conveniently.

All of our seats on our buses from Chicago to Louisville are equipped with onboard restrooms, individual power outlets, three-point seatbelts, and reclining seats.

Plus, when booking your bus tickets from Chicago to Louisville, you’re given multiple seating upgrade options to ensure your experience is as comfortable and relaxing as possible.

On all of our buses from Chicago to Louisville and Louisville to Chicago, we offer reserved seating.

Reserve one of the 10 most popular seats on our buses to enjoy a more spacious ride or secure seats next to family and friends (assuming you like them).

Remember that reserved seats are limited, so make sure to plan ahead and book early for your Chicago to Louisville trip!

Route information for the bus from Chicago to Louisville

Our bus route from Chicago to Louisville happens to be one of our most popular routes among our network of over 100 cities across North America, allowing you flexible scheduling.

With convenient departure times, Megabus makes planning your next Chicago to Louisville trip simple.

Keep track of your Chicago to Louisville itinerary online, easily accessible from your smartphone.

Bus stop locations and drop-off locations in Chicago and Louisville

Whether you’re traveling by bus from Chicago to Louisville or vice versa, you will be centrally located for hotels, restaurants, and public transit when you arrive.

When traveling by bus from Louisville to Chicago, you will depart from East Broadway, under the I-65 overpass between S. 1st Street and S. Brook Street.

Your Louisville to Chicago bus will arrive at Van Buren Street between South Canal and Clinton Street.

Learn more about Chicago and things to do by visiting our city guide.

When you travel by bus from Chicago to Louisville, you will depart from Van Buren Street between South Canal and Clinton Street.

Your Chicago to Louisville bus will arrive at East Broadway, under the I-65 overpass between S. 1st Street and S. Brook Street.

Learn more about Louisville and its sights by visiting our city guide.

You can check your reservation for the exact location and time of departure anytime online or from your smartphone.

Bus ticket prices for the bus from Chicago to Louisville

When booking in advance, you can save big on bus ticket pricing from Chicago to Louisville.

Megabus makes bus travel easy and affordable for your upcoming Chicago to Louisville trip, with fares as low as $1*.

Reserving your bus tickets for your next Chicago to Louisville trip is made simple online or by smartphone.

Our trip planner allows you to choose your flexible schedule for your Chicago to Louisville or Louisville to Chicago trip and find the itinerary that works for you.

Availability and booking for a bus from Chicago to Louisville

So if you’re planning on traveling by bus from Chicago to Louisville or from Louisville to Chicago, book your ticket with us today to reserve your seat and see our first-class amenities firsthand.

Learn more about fun things to do in Chicago or Louisville when you arrive.